| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1220846 | Journal of Pharmaceutical and Biomedical Analysis | 2015 | 4 Pages |
Abstract
•The small-angle X-ray scattering was applied to characterize the drug carrier system.•It was shown that the phospholipid transport nanosystem is vesicular system.•Size of vesicles was determined.
Phospholipid transport nanosystem (PTNS) for drug delivery is based on soybean phosphatidylcholine. The morphology of PTNS is investigated by means of small-angle X-ray scattering. The obtained results allow one to answer the key question from the viewpoint of organization of drug incorporation whether the PTNS nanoparticles have a structure of micelles or vesicles. It is demonstrated that PTNS is a vesicular system with an average vesicle radius of 160 ± 2 Å.
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Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
M.A. Kiselev, E.V. Zemlyanaya, O.M. Ipatova, A.Yu. Gruzinov, E.V. Ermakova, A.V. Zabelin, E.I. Zhabitskaya, O.S. Druzhilovskaya, V.L. Aksenov,