| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1220959 | Journal of Pharmaceutical and Biomedical Analysis | 2016 | 5 Pages |
Abstract
•Rapid and robust GC–FID based method of CDI analysis is presented.•Protocol involves a quick and simple derivatization of CDI with methanol.•Method has been validated and is easily transferable.
N,N-Carbonyldiimidazole (CDI), a common synthetic reagent used in commercial scale pharmaceutical synthesis, is known to be sensitive to hydrolysis from ambient moisture. This liability demands a simple, robust analytical method to quantitatively determine reagent quality to ensure reproducible performance in chemical reactions. This work describes a protocol for a rapid GC–FID based analysis of CDI.
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Claire Lee, Ian Mangion,