| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1221013 | Journal of Pharmaceutical and Biomedical Analysis | 2012 | 5 Pages |
Abstract
In this work, dissociation constants values of seven beta lactam antibiotics in water and acetonitrile–water mixtures using spectrophotometric and reversed phase liquid chromatography methods were determined. The dissociation constant values of these compounds were calculated by NLREG and STAR programs. Aqueous pKa values of beta lactam antibiotics were calculated with extrapolation by means of the Yasuda–Shedlovsky and mole fraction equations. Finally, application of the different techniques was compared to the determination of aqueous pKa values of investigated compounds.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ebru Çubuk Demiralay, Duygu Koç, Y. Doğan Daldal, Cansel Çakır,