Article ID Journal Published Year Pages File Type
1221606 Journal of Pharmaceutical and Biomedical Analysis 2011 5 Pages PDF
Abstract

The aggregation behaviour of casopitant mesylate, a new NK1 antagonist drug, was investigated by means of NMR spectroscopy and surface tension measurements. The critical micelle concentration (CMC) in glycine buffer at pH 3.5 was determined by analyzing the 1H NMR chemical shifts variation and the surface tension in function of the concentration in a series of solutions. The temperature dependence of the CMC was also evaluated by NMR spectroscopy as well as the thermodynamic parameters contributing to the aggregation discussed. Surface tension measurements were conducted as well in the formulation conditions, e.g. in the presence of sodium chloride.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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