| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1221736 | Journal of Pharmaceutical and Biomedical Analysis | 2010 | 5 Pages |
Abstract
AbstactDissociation constants of benzimidazole derivatives have been determined using capillary zone electrophoresis (CZE). Since CZE is a separation method, high purity and known concentration for the samples is not necessary because only mobilities are measured. The precision of pKa measurements of seven compounds is useful to observe pKa shifts induced by chemical variations. Some of them were compared to potentiometry and spectroscopy experiments. Good correlated pKa values are observed between the three analytical techniques.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Emmanuelle Lipka, Marcia Folly-Klan, Julie Charton, Marie-Pierre Vaccher, Jean-Paul Bonte, Claude Vaccher,