| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1221754 | Journal of Pharmaceutical and Biomedical Analysis | 2014 | 8 Pages |
Abstract
- Method developed for HOPO following categorization as a potential genotoxic impurity.
- Use of derivitization overcame challenges associated with direct analysis of HOPO.
- Method uses gas chromatography separation with mass spectrometry detection.
- Technology transferred for routine use in commercial API manufacturing.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Emma Quirk, Catrin Davies, Paul Foy, Alison Bretnall, Graham S. Clarke,