| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1221772 | Journal of Pharmaceutical and Biomedical Analysis | 2014 | 4 Pages |
•We identify four degradation products of cefpirome sulfate (CPS) by a hybrid ESI-Q-TOF mass spectrometer.•We estimate influence of temperature and relative air humidity (RH) on the stability of CPS.•We calculate kinetic and thermodynamic parameters of degradation of CPS in a solid state.
The process of degradation was studied by using an HPLC-DAD method. Four degradation products were identified with a hybrid ESI-Q-TOF mass spectrometer. The influence of temperature and relative air humidity (RH) on the stability of cefpirome sulfate was investigated. In the solid state the degradation of cefpirome sulfate was a first-order reaction depending on the substrate concentration. The kinetic and thermodynamic parameters of degradation were calculated.
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