| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1221827 | Journal of Pharmaceutical and Biomedical Analysis | 2012 | 4 Pages |
Abstract
Ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/QTOF MS) was employed to investigate the in vivo metabolism of liguzinediol. Urine, bile, feces and plasma samples were collected after intravenous administration of 10 mg/kg liguzinediol to healthy rats. Altogether seven metabolites were detected and tentatively identified based on the characteristics of their protonated ions. The metabolites were mainly transformed by four main metabolic pathways including oxidation, sulfation, glycine conjugation and glucuronidation.
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Authors
Chen-xiao Shan, Wei Li, Hong-mei Wen, Xin-zhi Wang, Yi-hang Zhu, Xiao-bing Cui,