| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1221843 | Journal of Pharmaceutical and Biomedical Analysis | 2010 | 10 Pages |
Abstract
Forced degradation of ritonavir (RTV), under the conditions of hydrolysis (acidic, basic and neutral), oxidation, photolysis and thermal stress as prescribed by ICH was studied using LC–MS/MS. Eight degradation products were formed and their separation was accomplished on Waters XTerra® C18 column (250 mm × 4.6 mm i.d., 5 μm) using water:methanol:acetonitrile as (40:20:40, v/v/v) mobile phase in an isocratic elution mode by LC. The method was extended to LC–MS/MS for characterization of the degradation products and the pathways of decomposition were proposed. No previous reports were found in the literature regarding the characterization of degradation products of ritonavir.
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
R. Nageswara Rao, B. Ramachandra, R. Mastan Vali, S. Satyanarayana Raju,