| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1221869 | Journal of Pharmaceutical and Biomedical Analysis | 2010 | 4 Pages |
Abstract
Stability studies of pramipexole dihydrochloride performed under following conditions of temperature and relative humidity (RH): 25 °C 60% RH and 40 °C 75% RH revealed its tendency to the water sorption and the monohydrate formation. The structural changes occurring during storage were studied by infrared spectroscopy and X-ray powder diffraction methods. The thermogravimetry technique was used to control the water sorption by the substance. Pramipexole dihydrochloride monohydrate was characterized by nuclear magnetic resonance and X-ray single crystal diffraction methods. The monohydrate crystallizes in the orthorhombic crystal system in the space group P212121.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Marta Łaszcz, Kinga Trzcińska, Marek Kubiszewski, Bożenna Kosmacińska, Magdalena Glice,