| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1221913 | Journal of Pharmaceutical and Biomedical Analysis | 2010 | 5 Pages |
Abstract
A new photoisomer of the promising “anti-Alzheimer” drug candidate (±) huperzine A is described. The new substance was formed via a photoisomerization reaction and was found to be 1-amino-13-ethylidene-11-methyl-6-aza-tetracyclo-[7.3.1.02.7.04.7]-trideca-2,10-diene-5-one using NMR analysis. The kinetics of its formation was studied and proven to be of first-order. The described photoisomer showed a significant loss in activity, being more than 100 times less active than (−) huperzine A itself. The new substance was named photohuperzine A, referring to its photopyridone substructure.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Lygia Azevedo Marques, Martin Giera, Frans J.J. de Kanter, Wilfried M.A. Niessen, Henk Lingeman, Hubertus Irth,