Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1222310 | Journal of Pharmaceutical and Biomedical Analysis | 2012 | 16 Pages |
Nine herbal dietary supplements intended to be beverages for enhancing sexual performance were analyzed before their possible launch on the market. Four of them contained a sildenafil analog reported for the first time as an adulterant. After isolation and characterization using NMR, MS, IR and UV, this analog was named propoxyphenyl-thiohydroxyhomosildenafil as the ethoxy chain on the phenyl ring of the already known analog thiohydroxyhomosildenafil was replaced by a propoxy moiety. One formulation was tainted with thiosildenafil, another unapproved PDE-5 inhibitor. Sildenafil along with the natural alkaloid tetrahydropalmatine that has no documented effect for enhancing erectile dysfunction were identified in two formulations. Another formulation was adulterated with phentolamine, a drug that is not approved for boosting male sexual performance when taken orally. The last formulation containing osthole, a bioactive natural coumarine improving sexual dysfunction, is most probably truly natural.
► Nine herbal dietary supplements were analyzed before their possible launch on the market. ► Four contained a new sildenafil analog adulterant named propoxyphenyl-thiohydroxyhomosildenafil. ► Two were tainted with sildenafil and tetrahydropalmatine, one with thiosildenafil and one with phentolamine. ► The last formulation containing osthole was probably truly natural. ► NMR, MSn, and accurate mass were used to characterize all compounds.