Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1222593 | Journal of Pharmaceutical and Biomedical Analysis | 2011 | 7 Pages |
Abstract
A set of indicator molecules was selected and applied to elaborate an NMR-based pH determination method, free of glass electrode errors in highly basic media. Accurate measurement of pH values and protonation constants was achieved by a successive build-up of overlapping, increasingly high pH solutions, using a collection of 8 compounds of appropriately incremented basicities.In order to verify the method, acid–base properties were quantified for two compounds with very high basicities in conflicting reports: two pharmaceutically important biguanidine drugs, metformin and phenformin.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Gábor Orgován, Béla Noszál,