Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1222594 | Journal of Pharmaceutical and Biomedical Analysis | 2011 | 7 Pages |
Abstract
1H NMR–pH titrations of arginine, the most basic natural amino acid and citrulline, its neutral counterpart were carried out. Two other closely related auxiliary compounds were also studied. The 8 macroscopic protonation constants were determined. Combining the four datasets in a deductive method, all the 12 microconstants of arginine, the 4 microconstants of citrulline and arginine amide were calculated. An error-propagation analysis and the pH-dependent distribution of the 8 arginine microspecies are provided.
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Gábor Orgován, Béla Noszál,