Article ID Journal Published Year Pages File Type
1222900 Journal of Pharmaceutical and Biomedical Analysis 2011 4 Pages PDF
Abstract

The composition of a volatile extract of Eryngium duriaei subsp. juresianum, signalised by the antifungal activity (MIC values = 0.16–0.32 μL mL−1) against several dermatophyte species (Trichophyton mentagrophytes, T. rubrum, Epidermophyton floccosum; T. verrucosum, T. mentagrophytes var interdigitale, Microsporum canis and M. gypseum) was established following a combined methodology of GC, GC–MS and an exclusive 13C NMR technique that does not require prior isolation of compounds. Twenty-five components were identified accounting 84.6% of the whole composition. Major compound was found to be α-neocallitropsene (26.0%) although the dominance of caryophyllane derived compounds, the most probable responsible for the antifungal activity, namely isocaryophyllen-14-al (16.2%), 14-hidroxy-β-caryophyllene (13.4%), caryophyllene oxide (7.6%) and E-β-caryophyllene (6.3%).

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Physical Sciences and Engineering Chemistry Analytical Chemistry
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