Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1222919 | Journal of Pharmaceutical and Biomedical Analysis | 2009 | 5 Pages |
Abstract
Successful use of LC–NMR and LC–MS for rapid identification of an impurity in a novel antifungal drug icofungipen has been demonstrated. Complementary information obtained from the two methods made it possible to determine the structure of A1 prior to its isolation and purification. Stop-flow LC–NMR (1H and DQFCOSY), LC–MS and LC–MS/MS spectra have shown that A1 is structurally related to icofungipen. It was later isolated and prepared synthetically and its structure was corroborated by high-resolution NMR spectroscopy.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Predrag Novak, Predrag Tepeš, Marina Ilijaš, Ines Fistrić, Igor Bratoš, Amir Avdagić, Zdenko Hameršak, Vesna Gabelica Marković, Miljenko Dumić,