| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1223105 | Journal of Pharmaceutical and Biomedical Analysis | 2008 | 7 Pages |
Abstract
An unknown degradation product (DP-1) increased in olmesartan medoxomil (OLM) tablets stored at 40 °C/75% r.h., reaching 0.72% after 6 months. The molecular weight and fragment information obtained by LC–MS suggested that DP-1 was a dehydrated dimer of olmesartan (OL) and the presence of ester carbonyl group was indicated by solvent-elimination LC–IR analysis. LC–1H NMR confirmed the structure of DP-1 as an esterified dimer of OL. Rapid and accurate identification of the degradation product was achieved by the complementary use of HPLC hyphenated techniques without complicated isolation or purification processes.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Tomonori Murakami, Hidetoshi Konno, Naoto Fukutsu, Michinobu Onodera, Takao Kawasaki, Fumiyo Kusu,