| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1223160 | Journal of Pharmaceutical and Biomedical Analysis | 2009 | 8 Pages |
Abstract
The stability of biapenem in aqueous solution was investigated. Forced degradation of biapenem was carried out under different concentrations, pH values and temperatures. The degradation products were determined by reverse-phase HPLC and identified by LC–MS/MS. One dimeric impurity was obtained by reverse-phase preparative HPLC and characterized by LC–MS/MS and NMR. A possible degradation mechanism has been presented.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ming Xia, Tai-Jun Hang, Fei Zhang, Xiao-Min Li, Xiang-Yang Xu,