Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1223181 | Journal of Pharmaceutical and Biomedical Analysis | 2009 | 5 Pages |
Abstract
The physico-chemical and structural characterization of diacerhein, an anthraquinone with antiinflammatory activity, employed in the symptomatic treatment of inflammatory osteoarthritis, is reported. The combined use of FT-IR, DSC, X-ray powder and single-crystal diffraction has provided a valuable tool to fully characterize the title compound. The X-ray diffraction study has revealed the existence of hydrogen-bond assisted tight packing of the quasi-planar molecules in the solid. The collected results are intended to implement the information required for the compilation of drug master files.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Massimo Bambagiotti-Alberti, Gianluca Bartolucci, Bruno Bruni, Silvia A. Coran, Massimo Di Vaira,