Simultaneous extraction of enrofloxacin and ciprofloxacin from chicken tissue by molecularly imprinted matrix solid-phase dispersion

An ofloxacin molecularly imprinted polymer was synthesized and used as a dispersant of matrix solid-phase dispersion for the determination of enrofloxacin and ciprofloxacin in chicken tissue. The selected dispersant shows high affinity to enrofloxacin and ciprofloxacin in aqueous environment and could selectively enrich them from chicken tissue matrix. The extract was sufficiently clean for further chromatographic analysis without interferences from template leakage or chicken tissue matrix. Linearity ranged from 0.03 to 200 μg/g with the correlation coefficient r2 > 0.9993. The recoveries of spiked chicken tissues were in the range of 82.7–96.6% for enrofloxacin and 88.7–102% for ciprofloxacin.