Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1223608 | Journal of Pharmaceutical and Biomedical Analysis | 2007 | 11 Pages |
Abstract
Solid phase extraction (SPE) has been utilized extensively in the pharmaceutical industry for the isolation of pharmaceuticals from interfering biological matrices and the purification and concentration of impurities and degradation products present in analytical samples. The work described herein involves the novel use of mixed-mode ion-exchange solid phase extraction to characterize degradation products of several pharmaceutical drugs, thereby giving important clues to their structure and sites of reactivity. Several examples of the use of mixed-mode ion-exchange solid phase extraction to illustrate the utility of this technique are presented.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Margaret S. Landis,