| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1223677 | Journal of Pharmaceutical and Biomedical Analysis | 2007 | 7 Pages |
Abstract
An impurity was detected in bulk drug Seroquel at about 0.4% level by the reversed-phase high-performance liquid chromatography with UV detection. The accurate mass of impurity was measured by FTICR equipped with electrospray ionization interface, and the structure of impurity was characterized on the basis of the on-line multi-stage mass spectrometric evidences. The proposed structure was further confirmed by multi-stage mass spectrometry of Seroquel and four related compounds.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Hui Xu, Danhua Wang, Cuirong Sun, Yuanjiang Pan, Minghua Zhou,