| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1223783 | Journal of Pharmaceutical and Biomedical Analysis | 2006 | 7 Pages |
Abstract
During the impurity profile of risperidone (RSP), a more polar impurity (RSP-1) and a more non-polar impurity (RSP-2) were detected in LC-MS with respect to risperidone. These impurities were isolated, enriched and were subjected to mass and NMR spectral studies. Based on the spectral data, RSP-1 and RSP-2 were characterized as risperidone N-oxide and 9-methylene risperidone, respectively. The formation of these impurities is rationalized. The structures of both the impurities were unambiguously confirmed by single crystal XRD Studies.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
P. Sattanathan, J. Moses Babu, K. Vyas, R.B. Reddy, S.T. Rajan, P. Sudhakar,