| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1223879 | Journal of Pharmaceutical and Biomedical Analysis | 2008 | 4 Pages |
Abstract
This paper proposes a method for estimating the detection limit, which is defined as 3.3 times the standard deviation (S.D.) of blank measurements under the situations where the repetition of measurement is difficult or impossible because of a short half-life of radioactivity. The FUMI theory, which can estimate an S.D. value without repetition in various instrumental analyses, is adopted and proved here to be available in a radio-HPLC system as well. 99mTc-ECD (T1/2 = 360.6 min) that is a lipophilic compound for the diagnosis of regional brain perfusion is taken as an example.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Akihito Kitajima, Takao Minamizawa, Toshimasa Toyo’oka, Rieko Matsuda, Yuzuru Hayashi,