Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1224243 | Journal of Pharmaceutical and Biomedical Analysis | 2007 | 7 Pages |
Abstract
Non-traditional sample preparation/extraction techniques that utilized the Caliper Life Sciences Tablet Processing Workstation II (TPW II), Microwave Assisted Extraction (MAE), and Accelerated Solvent Extraction (ASE) were evaluated for the extraction of Compound A from a 50Â mgA, 15% Spray Dried Dispersion (SDD) immediate released (IR) tablet formulation. The TPW II consistently provided complete recoveries with very short preparation/extraction times (â¼30Â min). MAE also provided complete recovery of the API from the tablet formulation, but required approximately twice the extraction time, while ASE provided the lowest recovery of the three non-traditional techniques. The sample preparation/extraction efficiencies of the three non-traditional techniques were compared to that of the 5.5Â h long manual method.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Carlos Lee, Jenny Gallo, William Arikpo, Vincent Bobin,