| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1224268 | Journal of Pharmaceutical and Biomedical Analysis | 2006 | 7 Pages |
Abstract
Three impurities were detected in the LC/MS analysis of fluconazole bulk drug substance. Two of the impurities were unknowns having not been reported previously. Structural assignment of these impurities was carried out by LC/MS/MS using electrospray ionization source and an ion trap mass analyzer. Structural elucidation using nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy was facilitated by newly developed rapid preparative isolation method. These impurities were characterized as 1-(1-H-1,2,4-triazole-1-yl) propane-2,3-diol and Z-2-(2,4-difluorophenyl)-3-(1-H-1,2,4-triazole-1-yl)-2-propen-1-ol. Their formation and synthesis are discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Vaijanath G. Dongre, Pravin P. Karmuse, Pradeep D. Ghugre, Sanjukumar M. Salunke, Nalinakshya Panda, Ashok Kumar,