Article ID Journal Published Year Pages File Type
1224451 Journal of Pharmaceutical and Biomedical Analysis 2007 6 Pages PDF
Abstract

Flow injection analysis (FIA) with amperometric detection was employed for acetaminophen quantification in pharmaceutical formulations using a carbon film resistor electrode. This sensor exhibited sharp and reproducible current peaks for acetaminophen without chemical modification of its surface. A wide linear working range (8.0 × 10−7 to 5.0 × 10−4 mol L−1) in phosphate buffer solution as well as high sensitivity (0.143 A mol−1 L cm−2) and low submicromolar detection limit (1.36 × 10−7 mol L−1) were achieved. The repeatability (R.S.D. for 10 successive injections of 5.0 × 10−6 and 5.0 × 10−5 mol L−1 acetaminophen solutions) was 3.1 and 1.3%, respectively, without any memory effect between injections. The new procedure was applied to the analyses of commercial pharmaceutical products and the results were in good agreement with those obtained utilizing a spectrophotometric method. Consequently, this amperometric method has been shown to be very suitable for quality control analyses and other applications with similar requirements.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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