| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1224478 | Journal of Pharmaceutical and Biomedical Analysis | 2007 | 5 Pages |
Abstract
The first flow-injection (FI) method for the determination of flutamide - a potent antiandrogen used for the treatment of prostate cancer - is reported. The method is based on the direct measurement of the absorbance of the analyte at 310Â nm under flow conditions. Parameters affecting the determination such as detection wavelength, sample injection volume and flow rate were studied and optimized. The assay was validated (linearity, limits of detection and quantitation, accuracy, repeatability, reproducibility and selectivity) for the dissolution studies of flutamide-containing tablets during stability testing. The results were in good agreement with high performance liquid chromatography (HPLC) used as a reference method.
Related Topics
Physical Sciences and Engineering
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Analytical Chemistry
Authors
Paraskevas D. Tzanavaras, Demetrius G. Themelis,