| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1224490 | Journal of Pharmaceutical and Biomedical Analysis | 2007 | 5 Pages |
Abstract
Characterization of nucleoside and non-nucleoside human immunodeficiency virus (HIV) reverse transcriptase inhibitors conformers, NRTIs and NNRTIs, respectively, is fundamental for an improved treatment of infected individuals. Three conformers in lamivudine I powder are quickly identified in this work by assignment of some Raman peaks to their vibrational frequencies, as obtained by first principles quantum chemical calculations. The method is proposed as a practical procedure for non-destructive identification, analysis, and process monitoring of NRTIs and NNRTIs conformers.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
B.G. Pereira, C.D. Vianna-Soares, A. Righi, M.V.B. Pinheiro, M.Z.S. Flores, E.M. Bezerra, V.N. Freire, V. Lemos, E.W.S. Caetano, B.S. Cavada,