Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1224505 | Journal of Pharmaceutical and Biomedical Analysis | 2006 | 8 Pages |
Abstract
AT1 antagonists constitute the most recent class of antihypertensive drugs which act through the Renin Angiotensin System (RAS). In an effort to comprehend their stereoelectronic features, a study was initiated to compare the conformational properties of drugs already marketed for the treatment of hypertension with synthetic ones, possessing common structural characteristics. In this study, the synthetic AT1 antagonist V8 is structurally elucidated and its conformational properties are studied through a combination of NMR spectroscopy and computational analysis. Its conformational properties are compared with those of the structurally similar prototype AT1 antagonist losartan.
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Physical Sciences and Engineering
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Analytical Chemistry
Authors
Panagiotis Zoumpoulakis, Aggeliki Politi, Simona Golic Grdadolnik, John Matsoukas, Thomas Mavromoustakos,