| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1224834 | Journal of Pharmaceutical and Biomedical Analysis | 2007 | 5 Pages |
Abstract
An automated solid-phase extraction method was developed for the determination of the H1-antihistamine acrivastine in plasma samples. Acrivastine was analyzed at the wavelength of 254 nm using a reversed-phase HPLC assay. Both extraction procedure and analytical condition were optimized and validated for maximum recovery and resolution. The developed method was further applied to plasma samples collected from an in vivo pharmacokinetic study in rabbits. The assay was found to be simple, specific, accurate and reproducible.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Benjamin R. Collins, Xiaochen Gu,