| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1224835 | Journal of Pharmaceutical and Biomedical Analysis | 2007 | 6 Pages |
Abstract
A simple procedure for obtaining and purifying two degradation products of efavirenz (amino alcohol and quinoline derivatives) from drug substance hydrolysis is described. These impurities are known to exhibit very different UV absorbance properties from those of the parent compound, making determination using a quantitation factor (QF) inaccurate. The obtained hydrolysis products were characterized by physicochemical methods to assure identity, purity and strength. Quinoline derivative was of high purity degree (100%) and amino alcohol was 98.74% pure. Both were set as reference standards in chromatographic related compounds test for efavirenz drug substance and tablets analyses.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
José Antônio de Aquino Ribeiro, Ligia Maria Moreira de Campos, Ricardo José Alves, Gustavo Portela Lages, Gerson Antônio Pianetti,