Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1224974 | Journal of Pharmaceutical and Biomedical Analysis | 2006 | 5 Pages |
Abstract
Three new compounds, 17α-acetoxy-2,6-dimethylpregna-1,4,6-triene-3,20-dione (1), 17α-acetoxy-2α,6-dimethylpregna-4,6-diene-3,20-dione (2), 17α-acetoxy-6α-methoxylmethylpregna-4-ene-3,20-dione (3), together with five known ones, 17α-acetoxy-6β-hydroxyl-6α-methylpregna-4-ene-3,20-dione (4), 17α-acetoxy-6α-hydroxyl-6β-methylpregna-4-ene-3,20-dione (5), 17α-acetoxy-pregna-4-ene-3,6,20-trione (6), 17α-acetoxy-pregna-4-ene-3,20-dione (7) and 17α-acetoxy-6-methylene-pregna-4-ene-3,20-dione (8), were isolated and identified from the residual mother liquor of megestrol acetate. Their structures were established by spectroscopic methods. These compounds seem to be minor impurities in production of the drug megestrol acetate.
Related Topics
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Authors
Fujiang Guo, Huijin Feng, Youfu Wang, Chune Zhang, Yuanchao Li,