Article ID Journal Published Year Pages File Type
1224974 Journal of Pharmaceutical and Biomedical Analysis 2006 5 Pages PDF
Abstract
Three new compounds, 17α-acetoxy-2,6-dimethylpregna-1,4,6-triene-3,20-dione (1), 17α-acetoxy-2α,6-dimethylpregna-4,6-diene-3,20-dione (2), 17α-acetoxy-6α-methoxylmethylpregna-4-ene-3,20-dione (3), together with five known ones, 17α-acetoxy-6β-hydroxyl-6α-methylpregna-4-ene-3,20-dione (4), 17α-acetoxy-6α-hydroxyl-6β-methylpregna-4-ene-3,20-dione (5), 17α-acetoxy-pregna-4-ene-3,6,20-trione (6), 17α-acetoxy-pregna-4-ene-3,20-dione (7) and 17α-acetoxy-6-methylene-pregna-4-ene-3,20-dione (8), were isolated and identified from the residual mother liquor of megestrol acetate. Their structures were established by spectroscopic methods. These compounds seem to be minor impurities in production of the drug megestrol acetate.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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