| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1225018 | Journal of Pharmaceutical and Biomedical Analysis | 2006 | 4 Pages |
Abstract
An LC-MS method using APCI has been developed and validated for the determination of the anticancer drug vincristine in human plasma, using vinblastine as internal standard. Following solid-phase extraction (SPE) of the sample, the lower limit of quantitation (LLOQ) was 0.18 ng/ml, the lower limit of detection was 0.09 ng/ml, and the linear calibration range was 0.18–180 ng/ml. This method has been used to measure plasma concentrations of vincristine from 0.08 to 24 h post bolus in 29 infants as part of a pharmacokinetic study. Concentrations of vincristine at 24 h were 0.2–1.36 ng/ml.
Related Topics
Physical Sciences and Engineering
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Authors
Mark S. Schmidt, Rong Huang, Robert J. Classon, Daryl J. Murry,