| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1225042 | Journal of Pharmaceutical and Biomedical Analysis | 2006 | 6 Pages |
Abstract
A novel stability-indicating high-performance liquid chromatographic assay method was developed and validated for docetaxel in the presence of degradation products generated from forced decomposition studies. A gradient HPLC method was developed to separate the drug from the degradation products, using a Hichrom RPB HPLC column. Mixture of water and acetonitrile was used as mobile phase. The flow rate was 1.0 ml/min and the detection was done at 230 nm. Using the above method one can carry out the quantitative estimation of impurity namely DCT-1 and docetaxel. The developed gradient LC method was subsequently validated.
Related Topics
Physical Sciences and Engineering
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Authors
B. Mallikarjuna Rao, Arpita Chakraborty, M.K. Srinivasu, M. Lalitha Devi, P. Rajender Kumar, K.B. Chandrasekhar, A.K. Srinivasan, A.S. Prasad, J. Ramanatham,