| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1225054 | Journal of Pharmaceutical and Biomedical Analysis | 2006 | 7 Pages |
Abstract
The assay of amodiaquine hydrochloride in pharmaceutical dosage forms using one of the proposed sensors gave average recoveries of 104.3 and 99.9 with R.S.D. of 0.3 and 0.6% for tablets (Malaritab®) and a reconstituted powder containing ADQ·2HCl, respectively. The sensor was also used for dissolution profile studies of two drug formulations. The sensor proved to have a good selectivity for ADQ·2HCl over some inorganic and organic compounds, however, berberine chloride interfered significantly. The results were validated by comparison with a spectrophotometric assay according to the USP pharmacopoeia.
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Authors
T. Kimbeni Malongo, B. Blankert, O. Kambu, K. Amighi, J. Nsangu, J.-M. Kauffmann,