| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1225065 | Journal of Pharmaceutical and Biomedical Analysis | 2006 | 6 Pages |
Abstract
Solubility measurements using chemiluminescent nitrogen detection (CLND) has advantages of reduced compound requirement and increased throughput compared to UV-spectrophotometric and HPLC-based measurements. CLND with direct flow injection was evaluated for the measurement of thermodynamic solubility to support drug discovery. The limit of quantitation (LOQ), accuracy, and day-to-day reproducibility of the detector were measured. Measurements made on CLND were compared to those obtained from UV spectrophotometry and HPLC. Based on the results obtained, it was concluded that the CLND performs satisfactorily for discovery stage thermodynamic solubility measurements.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Shobha N. Bhattachar, James A. Wesley, Christopher Seadeek,