Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1226392 | Journal of Trace Elements in Medicine and Biology | 2015 | 5 Pages |
Abstract
In the present review we provide an update of the appropriate use of chelating agents in the treatment of intoxications with compounds of mercury, lead and copper. The relatively new chelators meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercapto-propanesulphonate (DMPS) can effectively mobilize deposits of mercury as well as of lead into the urine. These drugs can be administered orally and have relatively low toxicity compared to the classical antidote dimercaptopropanol (BAL). d-Penicillamine has been widely used in copper overload, although 2,3-dimercaptosuccinic acid or tetrathiomolybdate may be more suitable alternatives today. In copper-toxicity, a free radical scavenger might be recommended as adjuvant to the chelator therapy.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Yang Cao, Marit Aralt Skaug, Ole Andersen, Jan Aaseth,