Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1226982 | Journal of Trace Elements in Medicine and Biology | 2013 | 6 Pages |
Abstract
SummaryMolecules naturally designed for the acquisition of essential metals can be used as a shuttle to deliver toxic metal ions to target organisms. In this study, we describe for the first time the synthesis of a derivative of cadmium and desferrioxamine B, a bacterial siderophore. The new compound was characterized by elemental analysis, vibrational (infrared and Raman) spectroscopy, mass coupled thermal analyses and X-ray diffraction methods. Studies on the in vitro toxicity toward a fungus and two bacterial strains indicated that the coordination compound is more active against microrganisms than cadmium chloride on a Cd-concentration basis, indicating that desferrioxamine can work as a “Trojan horse” in the delivery of a toxic metal.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ana Luiza Costa Mattos, Vera Regina Leopoldo Constantino, Ricardo Alexandre Alves de Couto, Delia Manuela Luna Pinto, Telma Mary Kaneko, Breno Pannia Espósito,