Redundancy of proteins in the salivary glands of Panstrongylus megistus secures prolonged procurement for blood meals

► A total of 45 proteins expressed in the P. megistus salivary glands have vasodilatation, anti-clotting, anti-platelet aggregation activities. The redundancy shown was considered important for the insect's remarkable adaptability to feeding upon different classes of vertebrates. ► Additionally, the P. megistus proteome revealed 159 proteins showing similarities with apyrase, lipocalins, thrombin inhibitor, trialysin, trypsin, and glutathione S-transferase. ► The main conclusion is that the P. megistus complex salivary gland bioamines have important functions associated with the insects' blood-feeding and resistance to insecticide.