Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1227206 | Journal of Trace Elements in Medicine and Biology | 2010 | 7 Pages |
Abstract
New La(III) and Dy(III) complexes of deprotonated 4-hydroxy-3[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one (Acenocoumarol) were synthesized and characterized using FT-IR, FT-Raman, 1H NMR spectra, and elemental analyses. The ligand and its lanthanide(III) complexes were tested for their cytotoxic/cytostatic activity against two tumor cell lines and peritoneal mouse macrophages. The La(III) and Dy(III) complexes exhibit good activity against melanoma B16 and fibrosarcoma L929 and they are stronger inhibitors of tumor cell proliferation compared to the ligand without influencing normal cell viability and NO release by mouse peritoneal macrophages.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Irena Kostova, Tsvetanka Stefanova,