Stability indicating methods for the analysis of cefprozil in the presence of its alkaline induced degradation product

•Comparative study between multivariate analysis and bivariate analysis•Can be applied for severely overlapped and complex binary mixtures•GA introduced less complex models.•Multivariate analysis transcended bivariate analysis.•Can be applied for analysis of the dosage form with no interference of excipients

Three simple, specific, accurate and precise spectrophotometric methods were developed for the determination of cefprozil (CZ) in the presence of its alkaline induced degradation product (DCZ). The first method was the bivariate method, while the two other multivariate methods were partial least squares (PLS) and spectral residual augmented classical least squares (SRACLS). The multivariate methods were applied with and without variable selection procedure (genetic algorithm GA). These methods were tested by analyzing laboratory prepared mixtures of the above drug with its alkaline induced degradation product and they were applied to its commercial pharmaceutical products.

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