| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1228940 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2016 | 4 Pages |
•Application of four different spectrophotometric methods•Simple methods were applied and validated as per ICH guideline.•Statistical comparison between the proposed methods and official method•One way ANOVA statistical analysis for comparison of the proposed methods
Four rapid, simple, accurate and precise spectrophotometric methods were used for the determination of ciprofloxacin in the presence of its acidic degradation product. The methods under study are ratio derivative, ratio difference, mean centering and dual wavelength. All the methods were validated according to the ICH guidelines and the obtained accuracy, precision and repeatability were found to be within the acceptable limits. The selectivity of the proposed methods was tested using laboratory prepared mixtures and assessed by applying the standard addition technique. So, they can be used for the routine analysis of ciprofloxacin in quality-control laboratories.
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