Two smart spectrophotometric methods for the simultaneous estimation of Simvastatin and Ezetimibe in combined dosage form

•The minimum sample preparation, low cost and the ease of using Excel software are the main advantages of these methods.•Regarding simplicity, modified ratio subtraction showed minimal data manipulation.•In modified ratio subtraction, simply ΔP is calculated at any two wavelengths in the ratio spectrum.•The derivative obtained using Savitsky–Golay function corrects for any interference.•Application of this function would eventually produce high degree of purity of analytical peaks.

Two simple, accurate, precise, sensitive and economic spectrophotometric methods were developed for the simultaneous determination of Simvastatin and Ezetimibe in fixed dose combination products without prior separation. The first method depends on a new chemometrics-assisted ratio spectra derivative method using moving window polynomial least square fitting method (Savitzky-Golay filters). The second method is based on a simple modification for the ratio subtraction method. The suggested methods were validated according to USP guidelines and can be applied for routine quality control testing.

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