| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1229848 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2014 | 7 Pages |
•We prepare a new Schiff base using cephalexin antibiotic.•We prepare cephalexin Schiff base transition metal complexes.•We study magnetic, spectroscopic properties and antibacterial activity.
Metal(II) coordination compounds of a cephalexin Schiff base (HL) derived from the condensation of cephalexin antibiotic with sulphathiazole were synthesized. The Schiff base ligand, mononuclear [ML(OAc)(H2O)2] (M(II) = Mn, Co, Ni, Zn) complexes and magnetically diluted trinuclear copper(II) complex [Cu3L(OH)5] were characterized by several techniques, including elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, EPR and 1H NMR spectral studies. The analytical and molar conductance values indicated that the acetate ions coordinate to the metal ions. The Schiff base ligand HL behaves as a monoanionic tridentate NNO and tetradentate NNOO chelating agent in the mono and trinuclear complexes respectively.
Graphical abstractTransition coordination compounds with a Schiff base (HL) derived from the condensation of cephalexin antibiotic with sulphathiazole were synthesized, characterized and screened for antibacterial activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
