Article ID Journal Published Year Pages File Type
1229857 Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2014 10 Pages PDF
Abstract

•Synthesis and characterization of HL and its metal complexes.•SOD-like activity exhibited those Cd(II) and Zn(II) complexes have strong antioxidative properties.•Ni(II) complex shows excellent activity similar to that of Fluorouracil for HePG2 and for MCF-7.

Here we present the synthesis of the new Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes with chelating ligand (Z)-(2-((1,3-diphenyl-1H-pyrazol-4-yl)methylene) hydrazinyl)(pyridin-2-ylamino)methanethiol. All the complexes were characterized by elemental analysis, IR, 1H NMR, UV–vis, magnetic susceptibility measurements and EPR spectral studies. IR spectra of complexes showed that the ligand behaves as NN neutral bidentate, NSN mononegative tridentate and NSNN mononegative tetradentate. The electronic spectra and the magnetic measurements suggested the octahedral geometry for all complexes as well as the EPR confirmed the tetragonal distorted octahedral for Cu(II) complex. Cd(II) complex showed the highest inhibitory antioxidant activity either using ABTS method. The SOD-like activity exhibited those Cd(II) and Zn(II) complexes have strong antioxidative properties. We tested the synthesized compounds for antitumor activity and showed that the ability to kill liver (HePG2) and breast (MCF-7) cancer cells definitely.

Graphical abstractThe synthesized compounds were tested for antitumor activity and showed that the ability to kill liver (HePG2) and breast (MCF-7) cancer cells significantly.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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