Synthesis, spectroscopic, anticancer and antibacterial studies of Ni(II) and Cu(II) complexes with 2-carboxybenzaldehyde thiosemicarbazone

•Synthesis and spectral characterizations of novel Schiff base ligand (2CBTS).•Preparation and spectral studies of Ni(II) and Cu(II) complexes of 2CBTS.•Antibacterial screening of ligand, Ni(II) and Cu(II) complexes.•Anticancer studies of 2CBTS and its Cu(II) complexes against MCF 7.

Ni(II) and Cu(II) complexes of 2-carboxybenzaldehyde thiosemicarbazone (L) were synthesized and investigated by their spectral and analytical data. These newly synthesized complexes have a composition of M(L)X(H2O)2 (where M = Ni(II), Cu(II) and X = Cl−, NO3-, CH3COO−) and (L) is the tridentate Schiff base ligand. The ligand and its complexes have been characterized on the basis of analytical, molar conductivity, magnetic susceptibility measurements, FT-IR, ESR, 1H NMR and electronic spectral analysis. All the compounds were non-electrolytic in nature. On the basis of spectral studies an octahedral geometry has been assigned for Ni(II) and a tetragonal geometry for Cu(II) complexes. The ligand and its metal complexes were screened for their anticancer studies against human breast cancer cell lines MCF-7 and calculated minimum inhibitory concentration and also for antibacterial activity using Kirby–Bauer single disk susceptibility test.

Graphical abstractTridentate Schiff base ligand 2-carboxybenzaldehyde thiosemicarbazone (L) and its Ni(II) and Cu(II) complexes were synthesized and characterized with spectral data. Synthesized complexes have a composition of M(L)X(H2O)2 (where M = Ni(II), Cu(II) and X = Cl−, NO3-, CH3COO−). Spectral studies reveals, an octahedral geometry for Ni(II) and a tetragonal geometry for Cu(II) complexes. Compounds were screened for anticancer studies against MCF-7 and calculated minimum inhibitory concentration and also for antibacterial activity using Kirby–Bauer single disk susceptibility test.Figure optionsDownload full-size imageDownload as PowerPoint slide