| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1230395 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2014 | 5 Pages |
•Synthesis and characterization of new quinazoline-4(3H)-one Schiff’s base and its La(III) complex.•Methicillin-resistant Staphylococcus aureus were isolated from Gulbarga region, India.•La(III) complex shows enhanced antimicrobial activity over Schiff’s base.
The incidence of methicillin-resistant Staphylococcus aureus increased during the past few decades, so there is an urgent need of new antimicrobial agents if public health is concerned. Though the Schiff’s bases and La(III) complex have enormous biological activity, but less attention was given in their synthesis. In the present investigation, we synthesized a new (E)-3-((2-hydroxynaphthalen-1-yl) methyleneamino)-2-methylquinazoline-4(3H)-one HNMAMQ Schiff’s base by the condensation of 3-(2-aminophenyl) quinazolin-2-methyl-4(3H)-one and 2-hydroxy-1-naphthaldehyde. The Schiff’s base HNMAMQ and its La(III) complex were characterized by elemental analyses, IR, NMR, mass spectra, and thermal studies. The newly synthesized Schiff’s base HNMAMQ and its La(III) complex were evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from the Gulbarga region in India. The Schiff’s base HNMAMQ and its La(III) complex showed good antimicrobial activity and thus represents a potential new drug of choice.
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