| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1230664 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2013 | 7 Pages |
Gold nanoparticles exhibit the optical properties of localized surface plamon resonance (LSPR) and are widely applied to the biosensors. The application of gold nanoparticles to the determination of anticancer drug 6-thioguanine (6-TG) was discussed. The binding of 6-TG molecule to the surface of gold nanoparticles alters the local refractive index in the vicinity of the nanoparticles and results in a shift of the LSPR spectrum. The experimental conditions were examined and optimized. Under the optimal conditions, the ratios of absorbances at two wavelengths are directly proportional to the concentrations of 6-TG. The developed method is simple, rapid, and sensitive. In addition, this method is particularly attractive because organic cosolvents, light-sensitive dyes, and sophisticated instruments are not required. This method was successfully applied to the determination of 6-TG in real samples and the results were satisfactory.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► 6-TG was determined based on localized surface plasmon resonance (LSPR) using gold nanoparticles as the probe. ► The proposed method is simple and sensitive. ► The sensitivity of gold nanorods was higher than gold nanospheres.
