Template synthesis, spectroscopic characterization and preliminary insulin-mimetic activity of oxovanadium(IV) complexes with N2O2 diazadioxa macrocycles

A new series of diazadioxa oxovanadium(IV) macrocyclic complexes of type [VO(mac)]SO4 have been synthesized via the condensation reaction of a 3-(phenyl/substituted phenyl)-4-amino-5-hydrazino-1,2,4-triazole (H2L) with salicylaldehyde/2-hydroxyacetophenone and 1,4-dibromobutane in the presence of oxovanadium(IV) sulfate in ethanol. All the newly synthesized compounds were characterized on the basis of elemental analyses, conductance measurements, magnetic properties, spectral (UV–Vis, IR, EPR) and XRD studies. The particle size of the complexes has been calculated from XRD spectra using Debye–Scherrer formula and these are found to be in 31–32 nm range. The efficacy of two macrocyclic complexes was also studied in streptozotocin-induced diabetic rats over a period of 30 days. The administration of these complexes in diabetic rats reversed the diabetic effect due to their insulin-mimetic effects.

Graphical abstractA new series of diazadioxa oxovanadium(IV) macrocyclic complexes of type [VO(mac)]SO4 have been synthesized and characterized. The efficacy of two macrocyclic complexes was also studied in streptozotocin-induced diabetic rats.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A new series of oxovanadium(IV) complexes have been synthesized. ► The complexes are monomeric, conducting, and paramagnetic in nature. ► X-ray diffraction showed that complexes are in 31–32 nm range. ► The complexes could be useful as a potential antidiabetic agent.